Custom PNA synthesis

PANAGENE has been supplying various designs of PNA (Peptide Nucleic Acid) oligo with high quality by PANAGENE's proprietary synthesis technology. All PNA (Peptide Nucleic Acid) oligos are manufactured and managed by strict quality control according to ISO9001/2000. With our excellent production technology and long experience in custom PNA (Peptide Nucleic Acid) oligo synthesis, we are able to supply PNA (Peptide Nucleic Acid) oligo that meets customer's needs. In addition, PANAGENE helps you design your PNA (Peptide Nucleic Acid) oligo and provides technical advices.

Gamma PNA

Gamma (γ)-PNA is a backbone-modified PNA that possesses a stereogenic center through modifications introduced at gamma (γ)-carbon of the backbone. Due to the stereogenic center, the gamma-PNA oligo itself forms an alpha-helical structure, thereby reducing the self-aggregation, improving the solubility and forming a more stable duplex with the target DNA. These features provide higher binding affinity to the target. In addition, various modifications such as internal multi-labeling are possible at any gamma (γ)-position. With these advantages, gamma (γ)-PNA can be an attractive material for diagnostics and drug development.

PNA FISH probe

Electrically neutral backbone, a key feature of PNAs, also provides advantages in FISH (fluorescent in situ hybridization). The high specificity of PNA by electrically neutral backbone enables rapid hybridization with just a small amount of PNA probe without significant background signal, resulting in high signal-to-noise ratio and washing under mild conditions. Telomere /centromere PNA FISH probes for telomere length analysis are available with a variety of fluorescence.

PNAs™ miRNA inhibitor

PANAGENE has developed PNAs™ miRNA inhibitors that are superior in specificity and stability to existing miRNA inhibitors, using PNA’s advantages. PNAs™ miRNA inhibitors are single stranded PNAs, which are an excellent tool for studying the function of miRNAs by specifically binding to endogenous miRNAs and effectively inhibiting their functionIn addition, PNAs™ miRNA inhibitors are combined with CPP (Cell Penetrating Peptide), so that transfection efficiency can be increased and it is possible to penetrate it even without transfection reagent in certain types of cells.